DHA and EPA reverse cystic fibrosis-related FA abnormalities by suppressing FA desaturase expression and activity
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چکیده
منابع مشابه
Cytokine-induced fever in obese ( fa/ fa) and lean ( Fa/ Fa) Zucker rats.
In earlier work, we reported that genetically obese ( fa/ fa) Zucker rats exhibited significantly greater anorexia than did lean ( Fa/ Fa) Zucker rats to intracerebroventricular infusion of interleukin (IL)-1β. Here, we investigated the fever response of obese ( fa/ fa) and lean ( Fa/ Fa) Zucker rats to intracerebroventricular microinfusion of IL-1β as well as to the following other cytokines: ...
متن کاملAdiposity and serum leptin increase in fatty (fa/fa) BNZ neonates without decreased VMH serotonergic activity.
Decreased ventromedial hypothalamic (VMH) serotonergic activity occurs in genetic and diet-induced animal models of obesity. We previously found that this activity was lower in adult and in 12-day-old Zucker fa/fa vs. Fa/Fa pups, the fa/fa animals being identified by their greater adiposity. In the present study, we evaluated fa/fa rats (Brown Norway-Zucker hybrids) at ages 2, 4, 7, and 12 days...
متن کاملAdipose tissue-specific increase in angiotensinogen expression and secretion in the obese (fa/fa) Zucker rat.
We investigated angiotensinogen (AGT) expression in adipose tissue and liver of Zucker rats during the onset of obesity. The developmental pattern of AGT expression (protein and mRNA) in liver was similar in both genotypes. In inguinal adipose tissue, AGT cell content was similar in suckling and weaned pups in lean rats, whereas it continuously increased with age in obese rats. AGT amount in ad...
متن کاملAdipose-tissue lipoprotein lipase activity and cellularity in the genetically obese Zucker rat (fa-fa).
The lipoprotein lipase activity per adipocyte was increased in the genetically obese rat (fa/fa). However, there was no difference between obese and lean animals when the enzyme activities were related to adipocyte surface area. The possible implications of the findings are discussed.
متن کاملLean ( Fa/ Fa) but not obese ( fa/ fa) Zucker rats release cholecystokinin at PVN after a gavaged meal.
Neuropeptides play an important role in the integration of dietary signals. Cholecystokinin (CCK) has been implicated in regulating ingestive behavior, particularly satiety. The primary objective of this study was to examine whether the hyperphagia characteristic of obese ( fa/ fa) rats involves impaired neural CCK secretion. Dynamic release of CCK at the hypothalamic paraventricular nucleus (P...
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ژورنال
عنوان ژورنال: Journal of Lipid Research
سال: 2012
ISSN: 0022-2275
DOI: 10.1194/jlr.m018101